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KMID : 0370220100540010022
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Yakhak Hoeji
2010 Volume.54 No. 1 p.22 ~ p.26
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Antimicrobial Activity of Resveratrol Oligomers and Flavonoids from the Stems of Vitis coignetiae Pulliat and the Seeds of Perilla frutescens (L.) Britton
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Son Rak-Ho
Chin Hwi-Seung
Ham Ah-Rom
Mar Woong-Chon
Nam Kung-Woo
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Abstract
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We studied the antimicrobial activities of five compounds isolated from the stems of Vitis coignetiae Pulliat and the seeds of Perilla frutescens (L.) Britton. Based on spectroscopic evidence, compounds 1 to 5 were characterized as resveratrol, -viniferin, ampelopsin E, apigenin, and luteolin, respectively. The antimicrobial activities against Gram-positive (Staphylococcus aureus) and -negative (Pseudomonas aeruginosa) bacteria and a fungus (Candida albicans) were investigated using the disc diffusion and broth dilution methods. C. albicans was not inhibited by the five compounds. Compounds 2 and 5 had significant anti-microbial activity against S. aureus, and the 50% inhibitory concentration () of compound 2 against S. aureus was 7.2 . Compounds 4 and 5 significantly inhibited P. aeruginosa and the minimum inhibitory concentration (MIC) of compounds 2 and 5 was 0.07 and 2.0 , respectively. Compounds 2, 4, and 5 had strong anti-microbial activity against S. aureus and P. aeruginosa.
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KEYWORD
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Vitis coignetiae, Perilla frutescens, antimicrobial
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